The Argonaute quest

Silence as the Ultimate Fulfillment of the Philosophical Quest

Argonaute proteins

Quick guides Why did you move back to China? First of all, I feel extremely privileged to be educated and trained at the University of Minnesota. There are many superb scientists studying vision and brain imaging there. My collaboration with them led to some intriguing findings on visual adaptation, unconscious visual processing, and contextual modulation in early visual cortical areas. From th...

Argonaute and Argonaute-Bound Small RNAs in Stem Cells.

Small RNAs are essential for a variety of cellular functions. Argonaute (AGO) proteins are associated with all of the different classes of small RNAs, and are indispensable in small RNA-mediated regulatory pathways. AGO proteins have been identified in various types of stem cells in diverse species from plants and animals. This review article highlights recent progress on how AGO proteins and A...

The Tetrahymena Argonaute-Binding Protein Giw1p Directs a Mature Argonaute-siRNA Complex to the Nucleus

Emerging evidence suggests that RNA interference (RNAi)-related processes act both in the cytoplasm and in the nucleus. However, the process by which the RNAi machinery is transported into the nucleus remains poorly understood. The Tetrahymena Argonaute protein Twi1p localizes to the nucleus and is crucial for small RNA-directed programmed DNA elimination. In this study, we identify Giw1p, whic...

the quest for an hiv vaccine